Overview

[11C]Yohimbine PET Study of alpha2-AR

Status:
Completed
Trial end date:
2019-01-21
Target enrollment:
Participant gender:
Summary
The main purpose of this study is to model tissue specific kinetics of [11C]Yohimbine in healthy male participants by positron emission tomography (PET) and the appropriate arterial input function (part A) ; to determine the reproducibility of measures (classical test-retest study, part B1) and to measure the blocking of [11C]Yohimbine uptake in the brain following single oral dose administration of clonidine (part B2).
Phase:
Phase 1
Details
Lead Sponsor:
Hospices Civils de Lyon
Treatments:
Adrenergic Agents
Clonidine
Yohimbine